Gymnema
Gymnema Sylvestre in Glyco Reset: Evidence and Cautions
Gymnema sylvestre is a climbing plant, and Glyco Reset lists its leaf extract as one of 21 names in a 200 mg blend. The label prints no amount for it. LiverTox says gymnema's value in diabetes has not been shown, and the amount usually studied is 400 mg, three times a day.
Written by the Glyco Reset label deskUpdated
The plant01
What is gymnema sylvestre?
Gymnema sylvestre is a woody climbing plant, and its leaf is sold in supplements, often for blood sugar and weight claims.
LiverTox says the leaf is available over the counter, and that it has not been approved as a therapy for any medical condition in the United States (LiverTox, Gymnema). Glyco Reset lists it as "Gymnema Leaf Extract", eighth in the printed blend order.
A leaf extract
The label names the leaf, not a tea or a powder.
No printed amount
Federal rules allow a blend to list one total.
On the label02
How much gymnema leaf extract is in Glyco Reset?
The label does not say. Gymnema leaf extract shares a 200 mg proprietary blend with 20 other names, and no single amount is printed.
The rule for blends requires the total weight and the names in descending order by weight (21 CFR 101.36 (eCFR), Supplement Facts and proprietary blends). So gymnema, listed eighth, is likely present in a smaller amount than the first seven names, but that is an inference from order, not a measured figure.
The most it could be is under 200 mg, and that would leave nothing for the other 20 names. The table puts the label next to the source.
| Item | Amount | Source |
|---|---|---|
| Glyco Reset blend total | 200 mg for 21 names | Printed label |
| Gymnema alone | Not shown | Printed label |
| Typical supplement amount | 400 mg, three times a day | LiverTox |
| Amounts used in trials | 300 to 500 mg, once or twice a day | LiverTox |
The gap03
How does the label compare with the gymnema amounts in studies?
Even if the whole blend were gymnema, 200 mg would be half of one 400 mg serving, and the studied pattern is three of those a day.
That is a ceiling, not an estimate. The bars show the gap only, and no trial used this product.
The comparison. NIH describes a 1997 trial of 1,000 mcg a day of chromium picolinate in adults with type 2 diabetes. The Adequate Intake is 20 to 35 mcg. (NIH ODS, Chromium fact sheet for professionals)
Read it with care. The studied amount comes from a different product, group and time span. It is not a recommended or effective dose, and no trial tested Glyco Reset.
The comparison. LiverTox gives a typical gymnema supplement amount of 400 mg three times daily. The label's 200 mg is shared by twenty-one names. (LiverTox, Gymnema)
Read it with care. The studied amount comes from a different product, group and time span. It is not a recommended or effective dose, and no trial tested Glyco Reset.
The comparison. LiverTox describes liver injury cases at about 800 mg to 1.8 g of extract a day. The whole blend is 200 mg. (LiverTox, Green Tea)
Read it with care. The studied amount comes from a different product, group and time span. It is not a recommended or effective dose, and no trial tested Glyco Reset.
Each full bar is the daily amount used in the one study or reference we cite. The filled part is the most the label could give per dropper: the whole 200 mg blend is shared by 21 names, so any one plant is a fraction of that. The label also does not say whether each name is a powder or an extract, so even this comparison is rough.
The research04
Does gymnema leaf extract work for diabetes?
Not that anyone has shown. LiverTox says the overall effectiveness of gymnema in treating diabetes has not been shown (LiverTox, Gymnema).
Lab and animal studies found glucose-lowering effects, and that is what led to its use. In human trials, fasting glucose fell a little, but hemoglobin A1C rose. Purity and strength are poorly standardized from one product to the next.
NCCIH adds that no herbal supplement has reliable evidence for helping people manage diabetes (NCCIH, Diabetes and Dietary Supplements). The ADA says supplements without a known deficiency show no benefit and are not proven for lowering glucose (ADA, Vitamins, Minerals, and Supplements (diabetes.org)).
So the fair reading is mixed: a signal in animals, a split result in people, and nothing on a 200 mg multi-ingredient drop.
Medicine check05
Is gymnema safe with diabetes medicine?
No source we read says gymnema is safe with diabetes medicine, and none tests the pair. Gymnema and diabetes medicine is a question for your pharmacist.
The ADA warns that some supplement ingredients could intensify the effects of diabetes medicines, which can cause low blood sugar (ADA, Vitamins, Minerals, and Supplements (diabetes.org)). Gymnema was studied for glucose, so the warning is a reason to ask, not a finding about this plant.
MedlinePlus tells people to keep taking metformin even when they feel well, and to tell their doctor and pharmacist about all supplements (MedlinePlus, Metformin). The same rule fits insulin and other prescribed medicine.
Keep taking what you were prescribed. Severe low blood sugar, fainting or a seizure is an emergency: call 911 (Mayo Clinic, Hypoglycemia).
Side effects06
What are the gymnema side effects?
The gymnema side effects documented in our sources are few. LiverTox scores gymnema D for liver injury, meaning a possible rare cause with weak attribution (LiverTox, Gymnema).
The one liver case it describes was a patient with type 2 diabetes who drank an herbal tea containing gymnema. A single case cannot prove cause, and the tea had other contents.
Because the blend has 21 names, a reaction cannot be pinned on gymnema alone. Signs worth a call to your doctor include:
- Yellow skin or eyes, or dark urine.
- Shakiness, sweating or confusion, which can be low blood sugar.
- Any new symptom after the first dropper.
See side effects and medicine interactions for the whole blend.
Before you buy07
What should you ask before using a gymnema product?
Ask three things: what the gymnema amount is, what you take it with, and who will watch your blood sugar. Only blood tests diagnose diabetes and prediabetes (NIDDK, Diabetes Tests & Diagnosis).
Show the label
Hand your pharmacist the full Glyco Reset label, with the gymnema line and the 200 mg total.
Name your medicines
List diabetes, blood pressure and liver-related medicines, even over-the-counter ones.
Agree on a plan
Ask whether you should check readings more often, and when to call.
The listed prices are on the pricing page. Confirm the price, shipping and guarantee at checkout.
FAQ08
Gymnema questions people ask
Is gymnema sylvestre in Glyco Reset?
Yes. The label lists Gymnema Leaf Extract as the eighth of 21 names in the 200 mg proprietary blend. No amount is printed for it, so how much one dropper holds is unknown.
What is gymnema leaf extract?
It is a concentrated preparation from the leaf of the gymnema plant. LiverTox says it is sold over the counter, is poorly standardized, and has not been approved as a therapy for any condition in the United States.
Does gymnema and diabetes medicine mix safely?
No source we read tests that pairing. The ADA warns that some supplements can intensify diabetes medicine and cause low blood sugar. Keep taking your prescribed medicine and ask a pharmacist before the first dropper.
What are the side effects of gymnema?
LiverTox rates gymnema D for liver injury, a possible rare cause. The single case it describes involved an herbal tea. Report yellow skin, dark urine or new symptoms to a doctor, and stop use if told to.
How much gymnema is usually studied?
LiverTox gives a typical supplement amount of 400 mg three times a day, and trials of 300 to 500 mg once or twice a day. The Glyco Reset blend totals 200 mg for 21 names.
Has gymnema been shown to help diabetes?
No. LiverTox says overall effectiveness for diabetes has not been shown. Human trials saw small drops in fasting glucose but higher A1C. No trial tested Glyco Reset.
Can gymnema cause low blood sugar?
Lab studies found glucose-lowering effects, and the ADA warns about stacking supplements on diabetes medicine. Low blood sugar is 70 mg/dL or lower. Call 911 for fainting or a seizure.
Who wrote this09
Written and reviewed by
Pages built from the bottle label and linked NIH, CDC, FDA, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is the information site of a U.S. stocking partner for Glyco Reset. It is not the manufacturer, and it is not the brand's sales page. We earn money when you buy through our order links.
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